Beilstein J. Org. Chem.2020,16, 140–148, doi:10.3762/bjoc.16.16
following three categories: (i) by Wittig or Doebnerreaction of indoles bearing a 3-aldehyde group; (ii) by 1,4- or 1,2-addition of α,β-enones or carbonyl compounds, followed by oxidation or elimination, respectively; (iii) by Pd-catalysed oxidative coupling of indoles with activated alkenes. Several
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Graphical Abstract
Figure 1:
Biologically and medicinally important 3-alkenylindoles.
Beilstein J. Org. Chem.2019,15, 1281–1288, doi:10.3762/bjoc.15.126
available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.
Keywords: antibacterial activity; Doebnerreaction; pyrazolo[3,4-b]pyridine carboxylic acids; Ugi reaction; Introduction
Modern medicinal
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Graphical Abstract
Scheme 1:
An overview of heterocyclic acids used in the Ugi reaction.